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Mauthner cell

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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="en" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr">The Mauthner cells are a pair of big and easily identifiable <a href="Neuron" title="Neuron">neurons</a> (one for each half of the body) located in the <a href="Rhombomere" title="Rhombomere">rhombomere</a> 4 of the <a href="Hindbrain" title="Hindbrain">hindbrain</a> in fish and <a href="Amphibian" title="Amphibian">amphibians</a> that are responsible for a very fast escape <a href="Reflex" title="Reflex">reflex</a> (in the majority of animals – a so-called C-start response). The cells are also notable for their unusual use of both chemical and <a href="Electrical_synapse" title="Electrical synapse">electrical</a> <a href="Synapses" class="mw-redirect" title="Synapses">synapses</a>.<a href="#cite_note-Korn2005-1">[1]</a>

<div class="mw-heading mw-heading2"><h2 id="Evolutionary_history">Evolutionary history</h2></div>

Mauthner cells first appear in <a href="Lampreys" class="mw-redirect" title="Lampreys">lampreys</a> (being absent in <a href="Hagfish" title="Hagfish">hagfish</a> and <a href="Lancelet" title="Lancelet">lancelets</a>),<a href="#cite_note-Bierman2009-2">[2]</a> and are present in virtually all <a href="Teleost" title="Teleost">teleost</a> fish, as well as in <a href="Amphibian" title="Amphibian">amphibians</a> (including <a href="Metamorphosis" title="Metamorphosis">postmetamorphic</a> <a href="Frog" title="Frog">frogs</a> and <a href="Toad" title="Toad">toads</a><a href="#cite_note-Will1986-3">[3]</a>). Some fish, such as <a href="Lumpsuckers" class="mw-redirect" title="Lumpsuckers">lumpsuckers</a>, seem to have lost the Mauthner cells however.<a href="#cite_note-Hale2000-4">[4]</a>

<div class="mw-heading mw-heading2"><h2 id="Role_in_behavior">Role in behavior</h2></div>

<div class="mw-heading mw-heading3"><h3 id="The_C-start">The C-start</h3></div>

A C-start is a type of a very quick startle or <a href="Escape_reflex" title="Escape reflex">escape reflex</a> that is employed by <a href="Bluegill#Adaptations" title="Bluegill">fish</a> and <a href="Amphibian" title="Amphibian">amphibians</a> (including <a href="Larvae" class="mw-redirect" title="Larvae">larval</a> <a href="Frogs" class="mw-redirect" title="Frogs">frogs</a> and toads). There are two sequential stages in the C-start: first, the head rotates about the <a href="Center_of_mass" title="Center of mass">center of mass</a> towards the direction of future escape, and the body of the animal exhibits a curvature that resembles a letter C; then, at the second stage, the animal is propelled forward.<a href="#cite_note-5">[5]</a> The duration of these stages varies from species to species from about 10 to 20 ms for the first stage, and from 20 to 30 ms for the second.<a href="#cite_note-Korn2005-1">[1]</a><a href="#cite_note-Hale2000-4">[4]</a> In fish this forward propulsion does not require contraction of the antagonistic <a href="Muscle" title="Muscle">muscle</a>, but results from the body stiffness and the <a href="Hydrodynamic" class="mw-redirect" title="Hydrodynamic">hydrodynamic</a> resistance of the <a href="Tail" title="Tail">tail</a>. When an antagonistic muscular contraction does occur during stage 2, the fish rotates in the opposite direction, producing a counter-turn, and a directional change.

<div class="mw-heading mw-heading3"><h3 id="The_role_of_the_Mauthner_cell_in_the_C-start_behavior">The role of the Mauthner cell in the C-start behavior</h3></div>

In cases when an abrupt <a href="Acoustics" title="Acoustics">acoustic</a>, <a href="Touch" class="mw-redirect" title="Touch">tactile</a> or <a href="Visual" class="mw-redirect" title="Visual">visual</a> stimulus elicits a single <a href="Action_potential" title="Action potential">action potential</a> in one M-cell, it always correlates with a <a href="Contralateral" class="mw-redirect" title="Contralateral">contralateral</a> C-start escape.<a href="#cite_note-zottoli1977-6">[6]</a> An extremely quick mutual <a href="Feedback" title="Feedback">feedback</a> <a href="Lateral_inhibition" title="Lateral inhibition">inhibitory</a> circuit then assures that only one M-cell reaches spiking threshold—as the C-start has to be <a href="Unilateral" class="mw-redirect" title="Unilateral">unilateral</a> by definition—and that only one action potential is fired.<a href="#cite_note-Korn2005-1">[1]</a>

The Mauthner cell-mediated C-start reflex is very quick, with about 5-10 ms latency between the acoustic/tactile <a href="Stimulus_(physiology)" title="Stimulus (physiology)">stimulus</a> and the Mauthner cell discharge, and only about 2 ms between the discharge and the unilateral muscle contraction.<a href="#cite_note-Korn2005-1">[1]</a><a href="#cite_note-zottoli1977-6">[6]</a> Mauthner cells are thus the quickest motor neuron to respond to the stimulus. It makes the C-start response behaviorally important as a way to initiate the escape reflex in an all or nothing fashion, while the direction and speed of the escape can be corrected later through the activity of smaller motor neurons.

In <a href="Larvae" class="mw-redirect" title="Larvae">larval</a> <a href="Zebrafish" title="Zebrafish">zebrafish</a> about ~60% of the total population of <a href="Reticulospinal" class="mw-redirect" title="Reticulospinal">reticulospinal</a> neurons are also activated by a stimulus that elicits the M-spike and C-start escape. A well-studied group of these reticulospinal neurons are the bilaterally paired M-cell <a href="Homologous_series" title="Homologous series">homologues</a> denoted MiD2cm and MiD3cm. These neurons exhibit morphological similarities to the M-cell including a lateral and ventral dendrite. They are located in <a href="Rhombomere" title="Rhombomere">rhombomeres</a> 5 and 6 of <a href="Hindbrain" title="Hindbrain">hindbrain</a> respectively, and also receive auditory input in parallel with the M-cell from the <a href="Cranial_nerve_VIII" class="mw-redirect" title="Cranial nerve VIII">pVIIIth nerve</a>. In fish, water jet stimuli that activate these neurons elicit non-mauthner initiated C-starts of a longer latency, compared with M-cell associated ones.

Although the M-cell is often considered the prototype of a <a href="Command_neuron" title="Command neuron">command neuron</a> in <a href="Vertebrate" title="Vertebrate">vertebrates</a>, this designation may not be fully warranted. Although electrical stimulation of the M-cell is sufficient for eliciting a C-start, this C-start is normally weaker than the one evoked by a sensory stimulus.<a href="#cite_note-7">[7]</a> Moreover, the C-start can be evoked even with the M-cell <a href="Ablation" title="Ablation">ablated</a>, although in this case the latency of the response increases.<a href="#cite_note-8">[8]</a> The most widely accepted model of the M-cell system, or brainstem escape network, is that the M-cell initiates a fixed action pattern to the left or right by activating a spinal motor circuit initially described by J. Diamond and colleagues, but the precise trajectory of the escape is encoded by population activity in the other classes of reticulospinal neurons functioning in parallel to the M-cell. This notion is supported by studies using in vivo calcium imaging in larval zebrafish which show that MiD2cm and MiD3cm are activated along with the M-cell when an offending stimulus is directed towards the head but not the tail, and are correlated with C-starts of a larger initial turn angle.

Another component of the escape response is mediated by cranial relay neurons that are activated by the Mauthner cell spike. These neurons are electrically coupled with motoneurons which innervate extraocular, jaw and opercular muscles and mediate pectoral fin adduction in <a href="Freshwater_hatchetfish" class="mw-redirect" title="Freshwater hatchetfish">hatchetfish</a>.<a href="#cite_note-Auerbach1969-9">[9]</a><a href="#cite_note-Eaton1977-10">[10]</a> This component of the neural circuit was first described by Michael V.L. Bennett and colleagues.

<div class="mw-heading mw-heading3"><h3 id="Mauthner_cells_in_other_types_of_behavior">Mauthner cells in other types of behavior</h3></div>

Mauthner cells may be involved into behavioral patterns other than the C-start, if these types of behavior also require extremely quick bending movement of the body. Thus in <a href="Goldfish" title="Goldfish">goldfish</a> Mauthner cells are activated during prey capture near the surface of the water, as this type of hunting is dangerous for the fish, and it would benefit from leaving the surface as soon as possible after the prey is captured.<a href="#cite_note-11">[11]</a>

In adult <a href="Metamorphosis" title="Metamorphosis">postmetamorphic</a> <a href="Anurans" class="mw-redirect" title="Anurans">anurans</a> (frogs and toads) that do not have a tail, M-cells are nevertheless preserved<a href="#cite_note-Will1986-3">[3]</a> and their discharges are associated with rapid movement of <a href="Leg" title="Leg">legs</a> during an escape.<a href="#cite_note-12">[12]</a> In addition, larval <a href="Lamprey" title="Lamprey">lampreys</a> (eel-like jawless fish of superclass Cyclostomata) exhibit rapid withdrawal behavior that is correlated with Mauthner cell activity and involves bilateral, posture-dependent muscular contractions along the length of the body.<a href="#cite_note-13">[13]</a> Larval lampreys (ammocoetes) are filter feeders that occupy crescent-shaped burrows in the silt or mud bottoms of freshwater stream beds, with their mouths positioned at, or just above the surface of the mud. Sudden vibration activates both Mauthner neurons in the lamprey brainstem, which causes an accordion-like muscular contraction in the trunk and tail and pulls the head down into the burrow.

<div class="mw-heading mw-heading2"><h2 id="Morphology_and_connections">Morphology and connections</h2></div>

<div class="mw-heading mw-heading3"><h3 id="Inputs_to_the_M-cell:_excitation_and_feed_forward_inhibition">Inputs to the M-cell: excitation and feed forward inhibition</h3></div>

The M-cell has two primary aspiny (lacking <a href="Dendritic_spine" title="Dendritic spine">dendritic spines</a>) <a href="Dendrite" title="Dendrite">dendrites</a> which receive segregated inputs from various parts of the neural system.<a href="#cite_note-Korn2005-1">[1]</a> One dendrite projects laterally and the other projects either in the ventral or medial direction, depending on the species.<a href="#cite_note-14">[14]</a>

The ventral dendrite receives information from the <a href="Optic_tectum" class="mw-redirect" title="Optic tectum">optic tectum</a><a href="#cite_note-zottoli1987-15">[15]</a> and <a href="Spinal_cord" title="Spinal cord">spinal cord</a><a href="#cite_note-16">[16]</a> while the lateral dendrite receives inputs from the octovolateralis systems (the <a href="Lateral_line" title="Lateral line">lateral line</a>, acoustic inputs from the <a href="Inner_ear" title="Inner ear">inner ear</a>, and inertial information from the statoliths brought by the <a href="Cranial_nerve_VIII" class="mw-redirect" title="Cranial nerve VIII">cranial nerve VIII</a>).<a href="#cite_note-Korn2005-1">[1]</a>

The fibers from the <a href="Ipsilateral" class="mw-redirect" title="Ipsilateral">ipsilateral</a> cranial nerve VIII terminate in excitatory mixed <a href="Electrical_synapse" title="Electrical synapse">electrical</a> and <a href="Glutamate" class="mw-redirect" title="Glutamate">glutamatergic</a> <a href="Synapses" class="mw-redirect" title="Synapses">synapses</a> on the M-cell. They also electrically activate <a href="Glycine" title="Glycine">glycinergic</a> inhibitory interneurons that terminate on the M-cells. Despite the inhibitory input having one more synapse in its pathway, there is no delay between the excitation and inhibition because the intervening synapse is electrical. It was shown that for weak stimuli the inhibition wins over the excitation, preventing the M-cell from a discharge, while for stronger stimuli excitation becomes dominant.<a href="#cite_note-Oda1995-17">[17]</a> The <a href="Inner_ear" title="Inner ear">Inner ear</a> afferents also terminate with electrical synapses on a population PHP inhibitory interneurons (see below) to provide an additional level of feed forward inhibition. The Mauthner cell also has <a href="GABA" title="GABA">GABA</a>-, <a href="Dopamine" title="Dopamine">dopamine</a>-, <a href="Serotonin" title="Serotonin">serotonin</a>- and <a href="Somatostatin" title="Somatostatin">somatostatinergic</a> inputs, each restricted to certain dendritic region.<a href="#cite_note-Korn2005-1">[1]</a>

Inputs from the optic tectum and the lateral line help control which way the C-startle bends by biasing the mauthner cells when there are obstacles in the vicinity. In cases where movement away from the stimulus is blocked, the fish may bend towards the disturbance.<a href="#cite_note-Korn2005-1">[1]</a><a href="#cite_note-18">[18]</a>

The Mauthner cell <a href="Axon_hillock" title="Axon hillock">axon hillock</a> is surrounded by a dense formation of neuropil, called the axon cap.<a href="#cite_note-Bierman2009-2">[2]</a> The high resistance of this axon cap contributes to the typical shape of the Mauthner cell field potential (see below). In its most advanced form the axon cap consists of a core, immediately adjacent to the Mauthner cell axon, and containing a network of very thin <a href="Myelin" title="Myelin">unmyelinated</a> fibers, and a peripheral part. This peripheral part contains the large unmyelinated fibers of the PHP neurons (see below) that mediate the inhibitory feedback to the Mauthner cell; the Mauthner cell itself also sends small dendrites from its axon hill to the peripheral part of the axon cap. Finally, the surface of the axon cap is covered with a cap wall composed of several layers of <a href="Astrocyte" title="Astrocyte">astrocyte</a>-like <a href="Glia" title="Glia">glial</a> cells. Both glial cells and the unmyelinated fibers are coupled with each other by means of <a href="Gap_junction" title="Gap junction">gap junctions</a>.<a href="#cite_note-zottoli2011-19">[19]</a>

Evolutionarily, the axon cap is a more recent development than the Mauthner cell itself, so some animals, such as <a href="Lamprey" title="Lamprey">lampreys</a> and <a href="Eel" title="Eel">eels</a>, while having functional Mauthner cells, don't have axon cap at all, while some other animals, such as <a href="Amphibia" class="mw-redirect" title="Amphibia">amphibia</a> and <a href="Lungfish" title="Lungfish">lungfish</a>, do have a very simplified version of it.<a href="#cite_note-Bierman2009-2">[2]</a>

<div class="mw-heading mw-heading3"><h3 id="Feedback_network">Feedback network</h3></div>

The main part of the Mauthner cell-associated network is the negative <a href="Feedback" title="Feedback">feedback</a> network, which assures that only one of the two Mauthner cells fires in response to the stimulus and that, whichever Mauthner cell fires, it does so only once. Both these requirements are quite natural considering that the consequences of a single Mauthner cell discharge are so strong; a failure to comply with these two rules would not only prevent the animal from escaping, but could even physically damage it. The fastest part of this negative feedback network, which is also the one closest to the Mauthner cell, is that of the so-called passive hyperpolarizing field potential or PHP neurons.<a href="#cite_note-Korn2005-1">[1]</a> The fibers of these neurons are located in the axon cap, and they receive inputs from both <a href="Ipsilateral" class="mw-redirect" title="Ipsilateral">ipsilateral</a> and <a href="Contralateral" class="mw-redirect" title="Contralateral">contralateral</a> Mauthner cells. The <a href="Field_potential" class="mw-redirect" title="Field potential">field potentials</a> of PHP neurons are strongly positive, and form a part of the 'Signature field potential' of the Mauthner cell (see below), with the early (ipsilaterally initiated) component being called the Extracellular Hyperpolarizing Potential (EHP), and the later (contralaterally initiated) component being sometimes addressed in the literature as the Late Collateral Inhibition (LCI).<a href="#cite_note-zottoli2011-19">[19]</a> The action of PHP neurons onto the Mauthner cells is mediated by electrical, and not chemical effects: the outward currents generated by the <a href="Action_potential" title="Action potential">action potentials</a> in axon cap fibers flow inward across the Mauthner cell <a href="Axon_hillock" title="Axon hillock">axon hillock</a> and hyperpolarize it.<a href="#cite_note-Korn2005-1">[1]</a>

<div class="mw-heading mw-heading3"><h3 id="Outputs">Outputs</h3></div>

The only <a href="Axon" title="Axon">axon</a> of the Mauthner cell reaches from the cell to the midline of the <a href="Hindbrain" title="Hindbrain">hindbrain</a>, promptly crosses it to the contralateral side, and then descends caudally along the <a href="Spinal_cord" title="Spinal cord">spinal cord</a>.<a href="#cite_note-zottoli2011-19">[19]</a> A single discharge of the M-cell achieves a whole set of parallel effects onto the spinal motor networks: 1) it monosynaptically excites large primary <a href="Motoneuron" class="mw-redirect" title="Motoneuron">motoneurons</a> at one side of the body; 2) disynaptically excites smaller motoneurons at the same side of the body; 3) initiates action potentials in inhibitory <a href="Interneuron" title="Interneuron">interneurons</a> electrically coupled to the M-cell axon, and by their means inhibits a) inhibitory interneurons still at the same side of the body (to prevent them from interfering with the C-start), as well as b) motoneurons at the other side of the body. As a result of this pattern of activation the quick <a href="Muscle" title="Muscle">muscles</a> at one side of the body contract simultaneously, while the muscles at the other side of the body relax.<a href="#cite_note-20">[20]</a>

<div class="mw-heading mw-heading2"><h2 id="Electrophysiology">Electrophysiology</h2></div>

<div class="mw-heading mw-heading3"><h3 id="Ephaptic_properties">Ephaptic properties</h3></div>

The inhibition of the M-cell by the PHP cells occurs by <a href="Ephaptic_coupling" title="Ephaptic coupling">ephaptic interactions</a>. The inhibition is brought about without a <a href="Chemical_synapse" title="Chemical synapse">chemical synapses</a> or <a href="Electrical_synapse" title="Electrical synapse">electrical synaptic</a> coupling having low resistance <a href="Gap_junctions" class="mw-redirect" title="Gap junctions">gap junctions</a> joining the cells. When the region of the PHP cell axon outside the axon cap depolarizes, the influx of positive charge into the cell through <a href="Voltage_gated_sodium_channel" class="mw-redirect" title="Voltage gated sodium channel">voltage gated sodium channels</a> is accompanied by a passive outflow of current from the PHP cell axon into the region bound by the axon cap. Due to the high resistance of the surrounding glial cells, the charge does not dissipate and the potential across the M-cell membrane is increased, hyperpolarizing it.

<div class="mw-heading mw-heading3"><h3 id="Signature_field_potential">Signature field potential</h3></div>

Because of its size, presence of a quick feedback network, and abundance of <a href="Electrical_synapse" title="Electrical synapse">electrical</a> and quasi-electrical (<a href="Ephaptic_coupling" title="Ephaptic coupling">ephaptic</a>) synapses, the Mauthner cell has a strong <a href="Field_potential" class="mw-redirect" title="Field potential">field potential</a> of a very characteristic shape.<a href="#cite_note-zottoli1977-6">[6]</a><a href="#cite_note-zottoli2011-19">[19]</a> This field potential starts with a high-amplitude potential sink up to tens of <a href="Volt" title="Volt">millivolts</a> in amplitude that originates from the Mauthner cell discharge, and which is closely followed by a positive potential, called Extrinsic Hyperpolarizing Potential or EHP, which is associated with the activity of the recurrent feedback network.<a href="#cite_note-Korn2005-1">[1]</a>

Due to its high amplitude, in some animals the negative part of Mauthner cell field potential can be detected up to several hundred micrometres away from the cell itself.<a href="#cite_note-zottoli1977-6">[6]</a> The positive components of the field potential are strongest in the axon cap, reaching amplitudes of 45 mV in adult goldfish.<a href="#cite_note-zottoli2011-19">[19]</a> With a knowledge of these properties of the field potential, it is possible to use field potential monitoring as a way to find the Mauthner cell body <a href="In_vivo" title="In vivo">in vivo</a>, or <a href="In_vitro" title="In vitro">in vitro</a> in a whole brain preparation, moving the recording electrode in the <a href="Hindbrain" title="Hindbrain">hindbrain</a>, while at the same time stimulating the <a href="Spinal_cord" title="Spinal cord">spinal cord</a>, thus evoking <a href="Antidromic" title="Antidromic">antidromic</a> action potentials in the Mauthner cell axon.<a href="#cite_note-zottoli2011-19">[19]</a>

<div class="mw-heading mw-heading2"><h2 id="Plasticity">Plasticity</h2></div>

Application of <a href="Serotonin" title="Serotonin">serotonin</a> was shown to increase inhibitory inputs to the M-cell, while application of <a href="Dopamine" title="Dopamine">dopamine</a> – to increase the amplitude of both chemical and electrical components of the VIIIth nerve responses via a <a href="G_protein" title="G protein">G protein</a>-mediated activation of postsynaptic <a href="D2_receptor" class="mw-redirect" title="D2 receptor">D2 receptor</a>.<a href="#cite_note-Korn2005-1">[1]</a> An activity-dependent <a href="Long-Term_Potentiation" class="mw-redirect" title="Long-Term Potentiation">LTP</a> can be evoked in M-cells by a high-frequency stimulation of the VIIIth nerve. Surprisingly, this LTP is <a href="Electrical_synapse" title="Electrical synapse">electrical synapse</a>-mediated, and is presumed to involve modification of the <a href="Gap_junction" title="Gap junction">gap junction</a> channels.<a href="#cite_note-Korn2005-1">[1]</a> A possibility of <a href="LTP_induction" title="LTP induction">LTP induction</a> by sensory stimuli <a href="In_vivo" title="In vivo">in vivo</a>,<a href="#cite_note-Korn2005-1">[1]</a> and the evidence for the LTP of inhibitory inputs to M-cells<a href="#cite_note-Oda1995-17">[17]</a> were also demonstrated.

Spontaneous preference in turn direction in young goldfish is correlated with one of the Mauthner cells being bigger than the other one. It is possible to change the preference of fish by raising them in conditions facilitating turns in a specific direction; this shift is accompanied by a correspondent change in M-cell sizes.<a href="#cite_note-21">[21]</a>

<div class="mw-heading mw-heading2"><h2 id="History_of_research">History of research</h2></div>

The Mauthner cell was first identified by the Viennese ophthalmologist <a href="Ludwig_Mauthner" title="Ludwig Mauthner">Ludwig Mauthner</a> in the <a href="Teleost" title="Teleost">teleost</a> fish for its associated neural circuit which mediates an escape response called the C-start or C-<a href="Startle" class="mw-redirect" title="Startle">startle</a> to direct the fish away from a predator.

The M-cell is a model system in the field of <a href="Neuroethology" title="Neuroethology">Neuroethology</a>. The M-cell system has served for detailed <a href="Neurophysiological" class="mw-redirect" title="Neurophysiological">neurophysiological</a> and <a href="Histological" class="mw-redirect" title="Histological">histological</a> investigations of <a href="Synaptic_transmission" class="mw-redirect" title="Synaptic transmission">synaptic transmission</a> and <a href="Synaptic_plasticity" title="Synaptic plasticity">synaptic plasticity</a>.<a href="#cite_note-Korn2005-1">[1]</a> Studies by Donald Faber and <a href="Henri_Korn" title="Henri Korn">Henri Korn</a> helped to establish the one <a href="Synaptic_vesicle" title="Synaptic vesicle">vesicle</a> hypothesis of <a href="Synaptic_transmission" class="mw-redirect" title="Synaptic transmission">synaptic transmission</a> in the <a href="Central_nervous_system" title="Central nervous system">CNS</a>. Other important research topics that have been investigated in the M-cell system include studies by Yoichi Oda and colleagues on inhibitory <a href="Long-term_potentiation" title="Long-term potentiation">long-term potentiation</a> and <a href="Audition" title="Audition">auditory</a> <a href="Classical_conditioning" title="Classical conditioning">conditioning</a> of the startle response, and studies by Alberto Pereda and colleagues on plasticity of <a href="Electrical_synapse" title="Electrical synapse">electrical synapses</a>. Other research topics investigated in the M-cell system include studies of <a href="Vertebral_column" class="mw-redirect" title="Vertebral column">spinal</a> neural networks and neural regeneration by Joe Fetcho and colleagues, as well as underwater <a href="Sound_localization" title="Sound localization">sound localization</a>, and the biophysics of computation in single neurons.

<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>

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</style><cite id="CITEREFKornFaber2005" class="citation journal cs1">Korn H, Faber DS (July 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.neuron.2005.05.019">"The Mauthner cell half a century later: a neurobiological model for decision-making?"</a>. Neuron. 47 (1): 13–28. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.neuron.2005.05.019">10.1016/j.neuron.2005.05.019</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15996545">15996545</a>.</cite>

</li>

<li id="cite_note-Bierman2009-2">^ <a href="#cite_ref-Bierman2009_2-0">a</a> <a href="#cite_ref-Bierman2009_2-1">b</a> <a href="#cite_ref-Bierman2009_2-2">c</a> <cite id="CITEREFBiermanZottoliHale2009" class="citation journal cs1">Bierman HS, Zottoli SJ, Hale ME (2009). "Evolution of the Mauthner axon cap". Brain Behav. Evol. 73 (3): 174–87. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000222562">10.1159/000222562</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19494486">19494486</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:25637965">25637965</a>.</cite>

</li>

<li id="cite_note-Will1986-3">^ <a href="#cite_ref-Will1986_3-0">a</a> <a href="#cite_ref-Will1986_3-1">b</a> <cite id="CITEREFWill_U1986" class="citation journal cs1">Will U (February 1986). "Mauthner neurons survive metamorphosis in anurans: a comparative HRP study on the cytoarchitecture of Mauthner neurons in amphibians". J. Comp. Neurol. 244 (1): 111–20. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fcne.902440109">10.1002/cne.902440109</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3081602">3081602</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:40706257">40706257</a>.</cite>

</li>

<li id="cite_note-Hale2000-4">^ <a href="#cite_ref-Hale2000_4-0">a</a> <a href="#cite_ref-Hale2000_4-1">b</a> <cite id="CITEREFHale_ME2000" class="citation journal cs1">Hale ME (October 2000). "Startle responses of fish without Mauthner neurons: escape behavior of the lumpfish (Cyclopterus lumpus)". Biol. Bull. 199 (2): 180–2. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2307%2F1542886">10.2307/1542886</a>. <a href="JSTOR_(identifier)" class="mw-redirect" title="JSTOR (identifier)">JSTOR</a> <a rel="nofollow" class="external text" href="https://www.jstor.org/stable/1542886">1542886</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11081724">11081724</a>.</cite>

</li>

<li id="cite_note-5"><a href="#cite_ref-5">^</a> <cite id="CITEREFEatonDiDomenicoNissanov1988" class="citation journal cs1">Eaton RC, DiDomenico R, Nissanov J (August 1988). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6569417">"Flexible body dynamics of the goldfish C-start: implications for reticulospinal command mechanisms"</a>. J. Neurosci. 8 (8): 2758–68. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.08-08-02758.1988">10.1523/JNEUROSCI.08-08-02758.1988</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6569417">6569417</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3411353">3411353</a>.</cite>

</li>

<li id="cite_note-zottoli1977-6">^ <a href="#cite_ref-zottoli1977_6-0">a</a> <a href="#cite_ref-zottoli1977_6-1">b</a> <a href="#cite_ref-zottoli1977_6-2">c</a> <a href="#cite_ref-zottoli1977_6-3">d</a> <cite id="CITEREFZottoli_SJ1977" class="citation journal cs1">Zottoli SJ (February 1977). <a rel="nofollow" class="external text" href="http://jeb.biologists.org/cgi/pmidlookup?view=long&pmid=858992">"Correlation of the startle reflex and Mauthner cell auditory responses in unrestrained goldfish"</a>. J. Exp. Biol. 66 (1): 243–54. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjeb.66.1.243">10.1242/jeb.66.1.243</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/858992">858992</a>.</cite>

</li>

<li id="cite_note-7"><a href="#cite_ref-7">^</a> <cite id="CITEREFNissanovEatonDiDomenico1990" class="citation journal cs1">Nissanov J, Eaton RC, DiDomenico R (May 1990). "The motor output of the Mauthner cell, a reticulospinal command neuron". Brain Res. 517 (1–2): 88–98. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0006-8993%2890%2991012-6">10.1016/0006-8993(90)91012-6</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2376010">2376010</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:28611729">28611729</a>.</cite>

</li>

<li id="cite_note-8"><a href="#cite_ref-8">^</a> <cite id="CITEREFEatonLavenderWieland1982" class="citation journal cs1">Eaton RC, Lavender WA, Wieland CM (1982). "Alternative neural pathways initiate fast-start responses following lesions of the mauthner neuron in goldfish". J. Comp. Physiol. 145 (4): 485–496. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2FBF00612814">10.1007/BF00612814</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:8529312">8529312</a>.</cite>

</li>

<li id="cite_note-Auerbach1969-9"><a href="#cite_ref-Auerbach1969_9-0">^</a> <cite id="CITEREFAuerbachBennett1969" class="citation journal cs1">Auerbach AA, Bennett MV (February 1969). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2202901">"Chemically mediated transmission at a giant fiber synapse in the central nervous system of a vertebrate"</a>. The Journal of General Physiology. 53 (2): 183–210. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1085%2Fjgp.53.2.183">10.1085/jgp.53.2.183</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2202901">2202901</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/4303656">4303656</a>.</cite>

</li>

<li id="cite_note-Eaton1977-10"><a href="#cite_ref-Eaton1977_10-0">^</a> <cite id="CITEREFEatonBombardieriMeyer1977" class="citation journal cs1">Eaton RC, Bombardieri RA, Meyer DL (February 1977). <a rel="nofollow" class="external text" href="http://jeb.biologists.org/cgi/pmidlookup?view=long&pmid=870603">"The Mauthner-initiated startle response in teleost fish"</a>. The Journal of Experimental Biology. 66 (1): 65–81. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjeb.66.1.65">10.1242/jeb.66.1.65</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/870603">870603</a>.</cite>

</li>

<li id="cite_note-11"><a href="#cite_ref-11">^</a> <cite id="CITEREFCanfieldRose1993" class="citation journal cs1">Canfield JG, Rose GJ (1993). "Activation of Mauthner neurons during prey capture". Journal of Comparative Physiology A. 172 (5): 611–618. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2FBF00213683">10.1007/BF00213683</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:20259458">20259458</a>.</cite>

</li>

<li id="cite_note-12"><a href="#cite_ref-12">^</a> <cite id="CITEREFWill_U1991" class="citation journal cs1">Will U (1991). "Amphibian Mauthner cells". Brain Behav. Evol. 37 (5): 317–32. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000114368">10.1159/000114368</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1657273">1657273</a>.</cite>

</li>

<li id="cite_note-13"><a href="#cite_ref-13">^</a> <cite id="CITEREFCurrie1991" class="citation journal cs1">Currie, SN (1991). <a rel="nofollow" class="external text" href="https://www.karger.com/Article/Abstract/114364">"Vibration-evoked startle behavior in larval lampreys"</a>. Brain Behav Evol. 37 (5): 260–271. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000114364">10.1159/000114364</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1933250">1933250</a>.</cite>

</li>

<li id="cite_note-14"><a href="#cite_ref-14">^</a> <cite id="CITEREFZottoliFaber2000" class="citation journal cs1">Zottoli SJ, Faber DS (1 November 2000). "The Mauthner Cell: What Has It Taught Us?". <a href="Neuroscientist" title="Neuroscientist">Neuroscientist</a>. 6: 26–38. <a href="CiteSeerX_(identifier)" class="mw-redirect" title="CiteSeerX (identifier)">CiteSeerX</a> <a rel="nofollow" class="external text" href="https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.116.1442">10.1.1.116.1442</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1177%2F107385840000600111">10.1177/107385840000600111</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:14633326">14633326</a>.</cite>

</li>

<li id="cite_note-zottoli1987-15"><a href="#cite_ref-zottoli1987_15-0">^</a> <cite id="CITEREFZottoliHordesFaber1987" class="citation journal cs1">Zottoli SJ, Hordes AR, Faber DS (January 1987). "Localization of optic tectal input to the ventral dendrite of the goldfish Mauthner cell". Brain Res. 401 (1): 113–21. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0006-8993%2887%2991170-X">10.1016/0006-8993(87)91170-X</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3815088">3815088</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:33442056">33442056</a>.</cite>

</li>

<li id="cite_note-16"><a href="#cite_ref-16">^</a> <cite id="CITEREFChangLinFaber1987" class="citation journal cs1">Chang YT, Lin JW, Faber DS (August 1987). "Spinal inputs to the ventral dendrite of the teleost Mauthner cell". Brain Res. 417 (2): 205–13. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0006-8993%2887%2990444-6">10.1016/0006-8993(87)90444-6</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3651811">3651811</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:23825121">23825121</a>.</cite>

</li>

<li id="cite_note-Oda1995-17">^ <a href="#cite_ref-Oda1995_17-0">a</a> <a href="#cite_ref-Oda1995_17-1">b</a> <cite id="CITEREFOdaCharpierMurayamaSuma1995" class="citation journal cs1">Oda Y, Charpier S, Murayama Y, Suma C, Korn H (September 1995). "Long-term potentiation of glycinergic inhibitory synaptic transmission". J. Neurophysiol. 74 (3): 1056–74. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1152%2Fjn.1995.74.3.1056">10.1152/jn.1995.74.3.1056</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7500132">7500132</a>.</cite>

</li>

<li id="cite_note-18"><a href="#cite_ref-18">^</a> <cite id="CITEREFEatonEmberley1991" class="citation journal cs1">Eaton RC, Emberley DS (November 1991). <a rel="nofollow" class="external text" href="http://jeb.biologists.org/content/161/1/469.long">"How stimulus direction determines the trajectory of the Mauthner-initiated escape response in a teleost fish"</a>. The Journal of Experimental Biology. 161 (1): 469–87. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjeb.161.1.469">10.1242/jeb.161.1.469</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1757775">1757775</a>.</cite>

</li>

<li id="cite_note-zottoli2011-19">^ <a href="#cite_ref-zottoli2011_19-0">a</a> <a href="#cite_ref-zottoli2011_19-1">b</a> <a href="#cite_ref-zottoli2011_19-2">c</a> <a href="#cite_ref-zottoli2011_19-3">d</a> <a href="#cite_ref-zottoli2011_19-4">e</a> <a href="#cite_ref-zottoli2011_19-5">f</a> <cite id="CITEREFZottoliWongAgostiniMeyers2011" class="citation journal cs1">Zottoli SJ, Wong TW, Agostini MA, Meyers JR (July 2011). "Axon cap morphology of the sea robin (Prionotus carolinus): mauthner cell is correlated with the presence of "signature" field potentials and a C-Type startle response". J. Comp. Neurol. 519 (10): 1979–98. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fcne.22617">10.1002/cne.22617</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21452211">21452211</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:27602754">27602754</a>.</cite>

</li>

<li id="cite_note-20"><a href="#cite_ref-20">^</a> <cite id="CITEREFFetcho_JR1991" class="citation journal cs1">Fetcho JR (1991). "Spinal network of the Mauthner cell". Brain Behav. Evol. 37 (5): 298–316. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000114367">10.1159/000114367</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1933252">1933252</a>.</cite>

</li>

<li id="cite_note-21"><a href="#cite_ref-21">^</a> <cite id="CITEREFShtanchaevMikhailovaDektyarevaKokanova2008" class="citation journal cs1">Shtanchaev RS, Mikhailova GZ, Dektyareva NY, Kokanova NA, Moshkov DA (November 2008). "Changes in the ventral dendrite of Mauthner neurons in goldfish after optokinetic stimulation". Neurosci. Behav. Physiol. 38 (9): 917–21. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs11055-008-9071-9">10.1007/s11055-008-9071-9</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18975109">18975109</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:31352657">31352657</a>.</cite>

</li>

</ol></div>

<div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2></div>

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<ul><li><cite id="CITEREFBhattOttoDepoisterFetcho2004" class="citation journal cs1">Bhatt DH, Otto SJ, Depoister B, Fetcho JR (July 2004). "Cyclic AMP-induced repair of zebrafish spinal circuits". Science. 305 (5681): 254–8. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2004Sci...305..254B">2004Sci...305..254B</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.1098439">10.1126/science.1098439</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15247482">15247482</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:35497854">35497854</a>.</cite></li>

<li><cite id="CITEREFEatonLeeForeman2001" class="citation journal cs1">Eaton RC, Lee RK, Foreman MB (Mar 2001). "The Mauthner cell and other identified neurons of the brainstem escape network of fish". Prog Neurobiol. 63 (4): 467–85. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0301-0082%2800%2900047-2">10.1016/S0301-0082(00)00047-2</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11163687">11163687</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:19271673">19271673</a>.</cite></li>

<li><cite id="CITEREFHaleKheirbekSchrieferPrince2004" class="citation journal cs1">Hale ME, Kheirbek MA, Schriefer JE, Prince VE (March 2004). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729858">"Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons"</a>. J Neurosci. 24 (12): 3070–6. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.5624-03.2004">10.1523/JNEUROSCI.5624-03.2004</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729858">6729858</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15044546">15044546</a>.</cite></li>

<li><cite id="CITEREFKohashiOda2008" class="citation journal cs1">Kohashi T, Oda Y (October 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671347">"Initiation of mauthner- or non-mauthner-mediated fast escape evoked by different modes of sensory input"</a>. J Neurosci. 28 (42): 10641–53. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.1435-08.2008">10.1523/JNEUROSCI.1435-08.2008</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671347">6671347</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18923040">18923040</a>.</cite></li>

<li><cite id="CITEREFOdaKawasakiMoritaKorn1998" class="citation journal cs1">Oda Y, Kawasaki K, Morita M, Korn H, Matsui H (July 1998). "Inhibitory long-term potentiation underlies auditory conditioning of goldfish escape behaviour". Nature. 394 (6689): 182–5. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1998Natur.394..182O">1998Natur.394..182O</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F28172">10.1038/28172</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9671301">9671301</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:4430180">4430180</a>.</cite></li>

<li><cite id="CITEREFO'MalleyKaoFetcho1996" class="citation journal cs1">O'Malley DM, Kao YH, Fetcho JR (December 1996). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0896-6273%2800%2980246-9">"Imaging the functional organization of zebrafish hindbrain segments during escape behaviors"</a>. Neuron. 17 (6): 1145–55. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0896-6273%2800%2980246-9">10.1016/S0896-6273(00)80246-9</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8982162">8982162</a>.</cite></li>

<li><cite id="CITEREFPeredaRashNagyBennett2004" class="citation journal cs1">Pereda AE, Rash JE, Nagy JI, Bennett MV (December 2004). "Dynamics of electrical transmission at club endings on the Mauthner cells". Brain Res Brain Res Rev. 47 (1–3): 227–44. <a href="CiteSeerX_(identifier)" class="mw-redirect" title="CiteSeerX (identifier)">CiteSeerX</a> <a rel="nofollow" class="external text" href="https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.662.9352">10.1.1.662.9352</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.brainresrev.2004.06.010">10.1016/j.brainresrev.2004.06.010</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15572174">15572174</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:9527518">9527518</a>.</cite></li>

<li><cite id="CITEREFWeissZottoliDoFaber2006" class="citation journal cs1">Weiss SA, Zottoli SJ, Do SC, Faber DS, Preuss T (December 2006). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjeb.02582">"Correlation of C-start behaviors with neural activity recorded from the hindbrain in free-swimming goldfish (Carassius auratus)"</a>. J Exp Biol. 209 (23): 4788–801. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjeb.02582">10.1242/jeb.02582</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17114411">17114411</a>.</cite></li>

<li><cite id="CITEREFZottoliFreemer2003" class="citation journal cs1">Zottoli SJ, Freemer MM (September 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjeb.00512">"Recovery of C-starts, equilibrium and targeted feeding after whole spinal cord crush in the adult goldfish Carassius auratus"</a>. J Exp Biol. 206 (17): 3015–29. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjeb.00512">10.1242/jeb.00512</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12878670">12878670</a>.</cite></li></ul>

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</style><div id="Neuroethology291" style="font-size:114%;margin:0 4em"><a href="Neuroethology" title="Neuroethology">Neuroethology</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Concepts</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Feed_forward_(control)" title="Feed forward (control)">Feedforward</a></li>

<li><a href="Coincidence_detection_in_neurobiology" title="Coincidence detection in neurobiology">Coincidence detector</a></li>

<li><a href="Umwelt" title="Umwelt">Umwelt</a></li>

<li><a href="Instinct" title="Instinct">Instinct</a></li>

<li><a href="Feature_detection_(nervous_system)" title="Feature detection (nervous system)">Feature detection</a></li>

<li><a href="Central_pattern_generator" title="Central pattern generator">Central pattern generator (CPG)</a></li>

<li><a href="NMDA_receptor" title="NMDA receptor">NMDA receptor</a></li>

<li><a href="Lateral_inhibition" title="Lateral inhibition">Lateral inhibition</a></li>

<li><a href="Fixed_action_pattern" title="Fixed action pattern">Fixed action pattern</a></li>

<li><a href="Krogh's_principle" title="Krogh's principle">Krogh's principle</a></li>

<li><a href="Hebbian_theory" title="Hebbian theory">Hebbian theory</a></li>

<li><a href="Anti-Hebbian_learning" title="Anti-Hebbian learning">Anti-Hebbian learning</a></li>

<li><a href="Sound_localization" title="Sound localization">Sound localization</a></li>

<li><a href="Ultrasound_avoidance" title="Ultrasound avoidance">Ultrasound avoidance</a> in insects</li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">People</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Theodore_Holmes_Bullock" title="Theodore Holmes Bullock">Theodore Holmes Bullock</a></li>

<li><a href="Walter_Heiligenberg" title="Walter Heiligenberg">Walter Heiligenberg</a></li>

<li><a href="Nikolaas_Tinbergen" title="Nikolaas Tinbergen">Niko Tinbergen</a></li>

<li><a href="Konrad_Lorenz" title="Konrad Lorenz">Konrad Lorenz</a></li>

<li><a href="Donald_Griffin" title="Donald Griffin">Donald Griffin</a></li>

<li><a href="Donald_Kennedy" title="Donald Kennedy">Donald Kennedy</a></li>

<li><a href="Karl_von_Frisch" title="Karl von Frisch">Karl von Frisch</a></li>

<li><a href="Erich_von_Holst" title="Erich von Holst">Erich von Holst</a></li>

<li><a href="J%C3%B6rg-Peter_Ewert" title="Jörg-Peter Ewert">Jörg-Peter Ewert</a></li>

<li><a href="Franz_Huber" title="Franz Huber">Franz Huber</a></li>

<li><a href="Bernhard_Hassenstein" title="Bernhard Hassenstein">Bernhard Hassenstein</a></li>

<li><a href="Werner_E._Reichardt" title="Werner E. Reichardt">Werner E. Reichardt</a></li>

<li><a href="Eric_Knudsen" title="Eric Knudsen">Eric Knudsen</a></li>

<li><a href="Eric_Kandel" title="Eric Kandel">Eric Kandel</a></li>

<li><a href="Nobuo_Suga" title="Nobuo Suga">Nobuo Suga</a></li>

<li><a href="Masakazu_Konishi" title="Masakazu Konishi">Masakazu Konishi</a></li>

<li><a href="Fernando_Nottebohm" title="Fernando Nottebohm">Fernando Nottebohm</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Methods</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Patch_clamp" title="Patch clamp">Patch clamp</a></li>

<li><a href="Slice_preparation" title="Slice preparation">Slice preparation</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Systems</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Animal_echolocation" title="Animal echolocation">Animal echolocation</a></li>

<li><a href="Waggle_dance" title="Waggle dance">Waggle dance</a></li>

<li><a href="Jamming_avoidance_response" title="Jamming avoidance response">Jamming avoidance response</a></li>

<li><a href="Vision_in_toads" title="Vision in toads">Vision in toads</a></li>

<li><a href="Frog_hearing_and_communication" title="Frog hearing and communication">Frog hearing and communication</a></li>

<li><a href="Infrared_sensing_in_snakes" title="Infrared sensing in snakes">Infrared sensing in snakes</a></li>

<li><a href="Caridoid_escape_reaction" title="Caridoid escape reaction">Caridoid escape reaction</a></li>

<li><a href="Vocal_learning" title="Vocal learning">Vocal learning</a></li>

<li><a href="Surface_wave_detection_by_animals" title="Surface wave detection by animals">Surface wave detection</a></li>

<li><a href="Electroreception_and_electrogenesis" title="Electroreception and electrogenesis">Electroreception and electrogenesis</a></li>

<li><a href="Mechanoreceptor" title="Mechanoreceptor">Mechanoreception</a>

<ul><li><a href="Lateral_line" title="Lateral line">Lateral line</a></li></ul></li></ul>

</div></td></tr><tr><td class="navbox-abovebelow hlist" colspan="2"><div>

<ul><li> Category</li>

<li> <a href="https://commons.wikimedia.org/wiki/Category:Neuroethology" class="extiw external" title="commons:Category:Neuroethology">Commons</a></li></ul>

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